What is UC and What are Current Treatments

UC is an autoimmune disease characterized by inflammatory ulceration of the mucosa lining of the large intestine, including the rectum and sometimes, all or part of the colon. There is no cure for UC.

As the disease progresses, it becomes a significant burden to both patients and payers:

Patient Stories

Maintenance treatments don’t eliminate UC flaring

“Even with my maintenance medicine, I have symptom flares that interrupt my life.”

— UC patient

Address Flares Quickly to Prevent Disease Progression

Chart shows location of medication 8 hours following dosage administration

Treating acute flares early slows disease progression and allows a patient to stay on a maintenance regimen longer before becoming refractory to the treatment and the need to change drug therapies. The risk of dramatic health crisis is greatest during the time of transition from one treatment to the next, when it is not known if the patient will be a responder to the new medication.

All UC flares start in the rectum. Addressing rectal flares early with suppository medication is optimal for preventing distal disease progression in the colon and quiets extraintestinal manifestations of the disease.